Antiulcerative Properties of Cabbage Juice on Indomethacin Induced Ulcer in Albino Rats

COJ Okonkwo; SO Maduka; I Onyebuchi; I Okwuonu

doi:10.47494/mesb.v13i.639

(1) COJ Okonkwo Department of Human Physiology, Faculty of Basic Medical Services, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria
Nigeria
(2) SO Maduka Department of Human Physiology, Faculty of Basic Medical Services, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria
Nigeria
(3) I Onyebuchi Department of Human Physiology, Faculty of Basic Medical Services, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria
Nigeria
(4) I Okwuonu Department of Human Physiology, Faculty of Basic Medical Services, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria
Nigeria
(*) Corresponding Author

DOI:

https://doi.org/10.47494/mesb.v13i.639

Keywords:

Antiulcerative Properties, Cabbage Juice, Albino Rats

Abstract

Cabbage (Brassica oleracae) is a leafy green biennal plant widely used as spice all over the world. It is usually grown as an annual vegetable crop and is available in various shades of green, as well as purple varieties. When cabbage is shredded and blended, it gives pure cabbage juice. Cabbage juice contains beta-carotene, vitamin C and fiber. This present study investigates the antiulcerative properties of cabbage juice on indomethacin- induced ulcer in adult wister rats. A total of twenty – five (25) male albino rats weighing between 120g – 160g was used for this study and were randomly selected into five (5) groups of six (6) rats per group.Gastric ulceration was induced in the animals by oral administration of 30mg/kg of indomethacin in all the groups of animals after fasting them for 24hours. they were deprived of food but had free access to water 24 hours prior to ulcer induction. Various degrees of ulceration have manifested in four hours after indomethacin administration. The animals were anaesthetized using diethylether and stomach was incised along the greater curvature and ulceration were scored. Data were analyzed using SPSS (Version 16) software package. The result shows that Brassica oleracae juice had a more significant healing effect at 750mg/kg than the other treated groups when compared with control, , this healing effect of the extract is as a result of the nutritional constituent (L-glutamine, S-methylmethionine, gefarnate and L-arginine).

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