The State of Local Immunity of the Mucous Membrane of the Larynx in Children is Normal and with Stenosing Recurrent Laryngotracheitis

Abstract

Features of the child's body: lability of interstitial metabolism, increased hydrophilicity of tissues, exhaustion of compensatory systems, etc. They can cause a rapid manifestation of the pathological condition. One of the frequent and severe manifestations of acute respiratory viral infections in infants, accompanied by respiratory distress, is acute stenosing laryngotracheitis. To study changes in indicators of local immunity of the mucous membrane of the larynx in patients with recurrent acute laryngotracheitis. We examined 36 sick children diagnosed with acute stenosing recurrent laryngotracheitis and 20 practically healthy children aged 2 to 5 years. When evaluating the correlation relationships, it was found that local immunity of the mucous membrane of the larynx is provided by the coordination of the work of the cellular link (neutrophils and epithelial cells) and humoral factors (immunoglobulins, VPA). From all this it follows that in healthy children, local immunity of the mucous membrane of the larynx is represented by neutrophils and antibodies. Adaptation is characterized by an increase in the functional properties of neutrophils and a slight increase in IgE production. Thus, in patients with acute and recurrent laryngotracheitis, the immune response of the mucous membrane of the larynx is characterized by the activation of humoral factors (antibodies and VPA), the absence of significant changes on the part of the cellular link, there is an increase in destructive processes affecting both epithelial and immunocomponent cells-neutrophils, the degree of immune response increases in sick children with multiple recurrent laryngotracheitis.