Synthetic and Biocidal Studies of Zn-Hydrazone Complexes
Keywords:
biocidal, Zn-hydrazone, complexes, synthesized, constituents, formulations, biologicalAbstract
A series of hydrazone derivatives were synthesized through multi-step reactions. The 2-(2-oxo-1,2,3,4-tetrahydroquinoline-7-yloxy)acetohydrazide was prepared from 7-hydroxy-3,4-dihydroquinolin-2(1H)-one as starting material. Then the condensation of 2-(2-oxo-1,2,3,4-tetrahydroquinoline-7-yloxy)acetohydrazide with different o-hydroxyaldehyde derivatives yielded into hydrazone derivatives . These hydrazone ligands were complexed with Zn (II) yielded complexes . The molecular structures of the hydrazones and Zn (II) complexes were characterized by FTIR, 1H and 13C NMR, LCMS, XRD, DSC-TGA, UV–Visible, Fluorescence and elemental analysis. The conductivity experiments showed that all the complexes are non-electrolytes. This is the first comprehensive review of the biological activity of hydrazone-transition metal complexes. Hydrazone complexes gained much attention because of their antifugial, antibacterial anticonvulsant, and analgesic, anti-inflammatory, antimalarial, antimicrobial, antituberculosis, anticancer, and antiviral activities. Additionally, some of the hydrazone complexes were used in treatment of iron overload diseases. One application, which reflects the importance of hydrazone complexes, is their use in detection and determination of metals and some organic constituents in pharmaceutical formulations.The Zn-hydrazone complexes also have biocidal properties.
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