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Medical Care for Patients with Acute Acetic Acid Poisoning with Exotoxic Shock

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Abstract

Relevance: Due to the wide availability of acetic acid, acute poisoning with acetic acid is one of the most common etiological factors of household poisoning throughout Uzbekistan, and their specific gravity is quite large from 8.5 to 14.7%, and the mortality rate reaches 19 - 22.5%.


The aim of the study was to identify early markers of the development of systemic inflammatory response syndrome and sepsis manifestations in patients with severe acute acetic acid poisoning.


Materials and methods: The study was conducted in 124 patients with acute acetic acid poisoning. As indicators of the activity of inflammation, the following were studied: the content of IL-6, IL - 10 and procalcitonin (PCT) in blood serum.


Results: The increase of IL-6 content in the blood of patients to the level of 54-214 pg/ml at admission was determined. With the development of sepsis, an increased concentration of IL-6 (up to 115 pg/ml) was observed up to the fifth day. The IL-10 content in the blood of patients with subsequent sepsis upon admission was significantly higher (56-113 pg/ml) than in the blood of patients without sepsis. The concentration of IL-10 correlated with the development of sepsis (r=0.8) and the frequency of deaths (r=0.5). The content of PCT increased starting from the third day in patients with sepsis to a level exceeding the diagnostic value for sepsis (2 ng/ml).

Abstract

Relevance: Due to the wide availability of acetic acid, acute poisoning with acetic acid is one of the most common etiological factors of household poisoning throughout Uzbekistan, and their specific gravity is quite large from 8.5 to 14.7%, and the mortality rate reaches 19 - 22.5%.


The aim of the study was to identify early markers of the development of systemic inflammatory response syndrome and sepsis manifestations in patients with severe acute acetic acid poisoning.


Materials and methods: The study was conducted in 124 patients with acute acetic acid poisoning. As indicators of the activity of inflammation, the following were studied: the content of IL-6, IL - 10 and procalcitonin (PCT) in blood serum.


Results: The increase of IL-6 content in the blood of patients to the level of 54-214 pg/ml at admission was determined. With the development of sepsis, an increased concentration of IL-6 (up to 115 pg/ml) was observed up to the fifth day. The IL-10 content in the blood of patients with subsequent sepsis upon admission was significantly higher (56-113 pg/ml) than in the blood of patients without sepsis. The concentration of IL-10 correlated with the development of sepsis (r=0.8) and the frequency of deaths (r=0.5). The content of PCT increased starting from the third day in patients with sepsis to a level exceeding the diagnostic value for sepsis (2 ng/ml).

Keywords

acetic acid poisoning
interleukins
procalciotonin
systemic inflammatory response
sepsis

Declarations

Conflict of Interest Statement

The author (s) declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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References

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Cite this article as:

S., Q. Z. ., & M., A. M. . (2022). Medical Care for Patients with Acute Acetic Acid Poisoning with Exotoxic Shock. Middle European Scientific Bulletin, 25, 143-145. Retrieved from https://cejsr.academicjournal.io/index.php/journal/article/view/1370
  • Submitted
    14 June 2022
  • Revised
    14 June 2022
  • Published
    13 June 2022