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Cytokine Status of Salivary Fluid in Patients with Coronavirus Infection

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Abstract

Purpose: The article presents the results of a study of 2 major cytokines interleukin-1 beta and TNF-α in 30 patients with COVID-19, depending on the severity.


Materials and methods: Immunological studies were carried out on 30 saliva in patients with moderate and severe COVID-19 at the Republican Specialized Center No. 2 for coronavirus infection in 2020. All studies were carried out in the laboratory of immunocytokines of the Institute of Immunology of the Academy of Sciences of the Republic of Uzbekistan.


Results: 1. Analysis of interleukin in patients with IL-1 beta in patients with COVID-19 showed that in the group of moderate patients, the concentration was increased by 2 times, and in the group of severe patients - by 2.7 times. A significant increase in TNF-α production in saliva was also found in patients with moderate and severe COVID-19 by 2.8 times and 4.9 times, respectively.


Conclusion: Increased values of IL-1 beta and TNF-α in saliva in patients with moderate and severe COVID-19 prove the presence of a current inflammatory process in this case and in the oral cavity.

Abstract

Purpose: The article presents the results of a study of 2 major cytokines interleukin-1 beta and TNF-α in 30 patients with COVID-19, depending on the severity.


Materials and methods: Immunological studies were carried out on 30 saliva in patients with moderate and severe COVID-19 at the Republican Specialized Center No. 2 for coronavirus infection in 2020. All studies were carried out in the laboratory of immunocytokines of the Institute of Immunology of the Academy of Sciences of the Republic of Uzbekistan.


Results: 1. Analysis of interleukin in patients with IL-1 beta in patients with COVID-19 showed that in the group of moderate patients, the concentration was increased by 2 times, and in the group of severe patients - by 2.7 times. A significant increase in TNF-α production in saliva was also found in patients with moderate and severe COVID-19 by 2.8 times and 4.9 times, respectively.


Conclusion: Increased values of IL-1 beta and TNF-α in saliva in patients with moderate and severe COVID-19 prove the presence of a current inflammatory process in this case and in the oral cavity.

Keywords

cytokines
interleukin-1 beta
TNF-α
saliva
COVID-19

Declarations

Conflict of Interest Statement

The author (s) declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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References

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Cite this article as:

Jabborova, F. U. . (2022). Cytokine Status of Salivary Fluid in Patients with Coronavirus Infection. Middle European Scientific Bulletin, 25, 140-142. Retrieved from https://cejsr.academicjournal.io/index.php/journal/article/view/1369
  • Submitted
    14 June 2022
  • Revised
    14 June 2022
  • Published
    14 June 2022