Granunolocytic responses to Parasitaemia of Plasmodium Falciparum Species in children (6-59 months) attending bulumktu comprehensive health center, Maiduguri, Borno State – Nigeria
DOI:
https://doi.org/10.47494/mesb.v10i.323Keywords:
Granunolocytic, plasmodium falciparum, MaiduguriAbstract
This study was conducted to assess the influence of Plasmodium falciparum parasitaemia on eosinophil and neutrophil in children (6-59months), at BulumkutuComprehensive Health Centre, Maiduguri, Bono State, between August to December 2018. A total of 210 children were enrolled in the study which consisted of 88 (41.90%) patients with positive P. falciparum malaria and 122 (58.10%) negative malaria. Hematological parameters were analyzed using sysmexhaematology auto-analyzer (2011), while the Giemsa stained slides thick and thin blood films were prepared from the stock solution, and tested for Plasmodium falciparum malaria and count of malaria parasite density. This study indicated that there was a positive correlation between parasite densities and granulocytes (neutrophil and eosinophil) of the malaria-infected subjects, as well as malaria infected males and females subjects respectively. (r2 = 0.63 5, p = 0.005), (r2 = 0.5 10, p = 0.005), (r2 = 0.602, p = 0.005), (r2 = 0.504, p 0.005), and (r2 = 0.890, p = 0.001), (r2 = 0.623, p = 0.005).
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References
Abro AH, Abdalla MU, Nadeem JY, Ahmed AS, Dujana A, Ahmed AS, Dujana A, Ahmed AS (2008). Malaria & hematological changes. Pakistani journal of medical science24:287-291.
Borno State Information, Federal Republic of Nigeria, National Bureau of Statistics; accessed 28 September 2015.
Breman J. (2001). The ears of the hippopotamus: manifestation, determinants, and estimates of the malaria burden. Ame. J.Trop. Med. Hyg. 64 (1-2): 1-11.
Center for Diseases Control and Prevention (2004). Biology of malaria, assessed online at www.CDC.gov-malerial biology-index.htm.
Cheesbrough, M (1999). District Laboratory practice in tropical countries. Cambridge University Press. Volume 1 pp.244-251.
Clark IA, Bud AC, Alleva LM, Cowden AB (2006). Human malaria disease: a consequence of inflammatory cytokine release. malaria journal, 5 (85): 2006.
Durack DT, Ackerman SJ, Loegering DA, Gleich GJ (1981).Purification of humaneosinophil-derived neurotoxin. Pork NatlAcadSci78:5165-9.
Erhart LM, Yingyuen K, Chuanak N, Laaobounchai A, Miller RS (2004). Hematologic and clinical indices of malaria in a semi-immune population of western Thailand.AmJ. Med. Hyg70 (1): 8-14.
Federal Ministry of Health (2005). National Malaria Control Programmein Nigeria. Annual report 1-7.
Gilles HM, Warrell DA (1993). In Bruce- watt's essential malariology, 3rd Ed. Edward Arnold pp. 19-24.
Maina RN, Walsh D, Gaddy C, Hongo G, Waitumbi J, Otieno L, Jones D, Ogutu BR (2010). Impact of Plasmodium falciparum infection on hematological parameters in children living in Western Kenya. M. J. 9, S4,
Ojukwu JU (2002). Patter and outcome of Paediatric malaria admissions in Abakaliki, Ebonyi, Nigeria.Medical Journal j (1), 1720.
Pavithran K (2007). Hematological changes in Malaria. Clinical pharmacology 1:1-3.
Perrin LH, Mackey LJ,Miescher PA(1982). The hematology of malaria in man. Semin Hematology 19, 70-82.
Pukrittayakarnee S, White NJ, ClemensR (1989). Activation of the coagulation cascade in falciparum malaria. Trans. R. Soc. Trop. Med. Hyg. 83: 762-66.
Walters LS,Taverne J, Tai PC, Spry CJF, Targett GAT, Playfair JHL (1987). The killing of Plasmodium falciparimby eosinophil secretory products. Infect immune. 55:877 – 881
Weatherah DJ, Abdalla, SH (1998). Anemia of Plasmodiumfalciparum Malaria.Br. Med Bull. 2 (38):147-151.
World Health Organization (2008).WHO Guidelines for the Treatment of Malaria. Geneva, Switzerland”: Technical document, WHO/HTM/MAL/2006.1108,
World Health Organization, (2008). World Malaria Report W.H.O – Global Malaria Programme, Geneva.
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