Application of Chromatography in Medicine

    (*) Corresponding Author


chromatographic separation technique, thin layer chromatography, High-performance liquid chromatography, elution time, applications


Chromatography  is  a  separation  process  used  to  separate  components  in  a  mixture.  The components of the mixture are dispersed in a liquid solution known as the mobile phase., which holds  it through  a structure  containing  another substance  known  as the  stationary  phase. Component  separation requires differential partitioning between the  mobile and  stationary phases. The analytical goal of chromatography is to determine the qualitative and quantitative chemical makeup of a sample, and its primary purpose is to purify and extract one or more components of a sample. This paper will discuss the history and basics of what chromatography is meant and the main principles of how we can run it. besides, we will mention and focus on an  application  for each chromatographic  type such  as planar,  TLC, gas,  liquid separation techniques.


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Nguyen, J.M & Lauber, M.A – Comprehending COVID-19:

Reversed-Phase Liquid Chromatography (RPLC) of Intact SARS-CoV-2 Spike Protein

[Accessed Online 5th January 2021], J.C. et al (2020) Quantification of plasma remdesivir and its metabolite GS-441521 using liquid chromatography coupled to tandem mass spectrometry.

Application to a Cov-19 treated patient Clinical Chemistry and Laboratory Medicine (CCLM) 58:9 [Accessed Online 5th January 2021],

D.M et al (2020) Diagnosis of COVID-19 by analysis of breath with gas chromatography-ion mobility spectrometry – a feasibility study EClinical Medicine 29-30, 100609 [Accessed Online 5th January 2021]



How to Cite

Application of Chromatography in Medicine. (2024). Middle European Scientific Bulletin, 44(1), 44-46. Retrieved from




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